Peterman JE, Arena R, Myers J, Ades PA, Bonikowske AR, Harber MP, Marzolini S, Savage PD, Squires RW, Lavie CJ, Kaminsky LA
Purpose:Nonexercise predictions of peak oxygen uptake (Vo(2peak)) are used clinically, yet current equations were developed from cohorts of apparently healthy individuals and may not be applicable to individuals with cardiovascular disease (CVD). Our purpose was to develop a CVD-specific nonexercise prediction equation for Vo(2peak). Methods:Participants were from the Fitness Registry and Importance of Exercise International Database (FRIEND) with a diagnosis of coronary artery bypass surgery (CABG), myocardial infarction (MI), percutaneous coronary intervention (PCI), or heart failure (HF) who met maximal effort criteria during a cardiopulmonary exercise test (n = 15 997; 83% male; age 63.1 +/- 10.4 yr). The cohort was split into development (n = 12 798) and validation groups (n = 3199). The prediction equation was developed using regression analysis and compared with a previous equation developed on a healthy cohort. Results:Age, sex, height, weight, exercise mode, and CVD diagnosis were all significant predictors of Vo(2peak). The regression equation was:Vo(2peak) (mL center dot kg(-1) center dot min(-1)) = 16.18 - (0.22 x age [yr]) + (3.63 x sex [male = 1; female = 0]) + (0.14 x height [cm]) - (0.12 x weight [kg]) + (3.62 x mode [treadmill = 1; cycle = 0]) - (2.70 x CABG [yes = 1, no = 0]) - (0.31 x MI [yes = 1, no = 0]) + (0.37 x PCI [yes = 1, no = 0]) - (4.47 x HF [yes = 1, no = 0]). Adjusted R-2 = 0.43; SEE = 4.75 mL center dot kg(-1) center dot min(-1).Compared with measured Vo(2peak) in the validation group, percent predicted Vo(2peak) was 141% for the healthy cohort equation and 100% for the CVD-specific equation. Conclusions:The new equation for individuals with CVD had lower error between measured and predicted Vo(2peak) than the healthy cohort equation, suggesting population-specific equations are needed for predicting Vo(2peak); however, errors associated with nonexercise prediction equations suggest Vo(2peak) should be directly measured whenever feasible.