Association of Depression and Cardiovascular Disease Article

Full Text via DOI: 10.1016/j.amjmed.2023.04.036 Web of Science: 001060062500001

Cited authors

  • Krittanawong C, Maitra NS, Qadeer YK, Wang Z, Fogg S, Storch EA, Celano CM, Huffman JC, Jha M, Charney DS, Lavie CJ


  • BACKGROUND: Cardiovascular disease remains the leading worldwide cause of mortality. There has been increased awareness of the impact of psychological health on cardiovascular disease. In particular, major depression has been linked to increased all-cause mortality, development of cardiovascular disease, and worse outcomes in those with existing cardiovascular disease.METHODS: We conducted a meta-analysis assessing the incidence of cardiovascular disease and cardiovascular disease outcomes among those with major depressive disorder.RESULTS: Among 26 studies of 1,957,621 individuals, depression was associated with increased risk of incident stroke (hazard ratio [HR] 1.13; 95% confidence interval [CI], 1.00-1.28), myocardial infarction (HR 1.28; 95% CI, 1.14-1.45), congestive heart failure (HR 1.04; 95% CI, 1.00-1.09), or any cardiovascular disease (HR 1.16; 95% CI, 1.04-1.30). Depression was associated with increased risk of all-cause mortality (HR 1.43; 95% CI, 1.27-1.60), cardiovascular disease mortality (HR 1.44; 95% CI, 1.27-1.63), andCONCLUSION: Depression has a significant negative impact on development of cardiovascular disease and on cardiovascular disease outcomes. Further efforts to understand and mitigate these impacts are prudent. & COPY; 2023 Elsevier Inc. All rights reserved. & BULL; The American Journal of Medicine (2023) 136:881-895

Publication date

  • 2023

Published in

International Standard Serial Number (ISSN)

  • 0002-9343

Number of pages

  • 15

Start page

  • 881

End page

  • 895


  • 136


  • 9