Hospitalizations for Acute Salicylate Intoxication in the United States Article

Full Text via DOI: 10.3390/jcm9082638 PMID: 32823834 Web of Science: 000567711600001
Open Access International Collaboration

Cited authors

  • Thongprayoon, Charat; Petnak, Tananchai; Kaewput, Wisit; Mao, Michael A.; Kovvuru, Karthik; Kanduri, Swetha R.; Boonpheng, Boonphiphop; Bathini, Tarun; Vallabhajosyula, Saraschandra; Pivovarova, Aleksandra I.; Brar, Himmat S.; Medaura, Juan; Cheungpasitporn, Wisit


  • Background: The objective of this study was to describe inpatient prevalence, characteristics, outcomes, and resource use for acute salicylate intoxication hospitalizations in the United States. Methods: A total of 13,805 admissions with a primary diagnosis of salicylate intoxication from 2003 to 2014 in the National Inpatient Sample database were analyzed. Prognostic factors for in-hospital mortality were determined using multivariable logistic regression. Results: The overall inpatient prevalence of salicylate intoxication among hospitalized patients was 147.8 cases per 1,000,000 admissions in the United States. The average age was 34 +/- 19 years. Of these, 35.0% were male and 65.4% used salicylate for suicidal attempts. Overall, 6% required renal replacement therapy. The most common complications of salicylate intoxication were electrolyte and acid-base disorders, including hypokalemia (25.4%), acidosis (19.1%), and alkalosis (11.1%). Kidney failure (9.3%) was the most common observed organ dysfunction. In-hospital mortality was 1.0%. Increased in-hospital mortality was associated with age >= 30, Asian/Pacific Islander race, diabetes mellitus, hyponatremia, ventricular arrhythmia, kidney failure, respiratory failure, and neurological failure, while decreased in-hospital mortality was associated with African American and Hispanic race. Conclusion: hospitalization for salicylate intoxication occurred in 148 per 1,000,000 admissions in the United States. Several factors were associated with in-hospital mortality.

Publication date

  • 2020

Published in


  • 9


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