Skin preparation type and post-cesarean infection with use of adjunctive azithromycin prophylaxis Article

Full Text via DOI: 10.1080/14767058.2020.1797665 PMID: 32727231 Web of Science: 000555125200001

Cited authors

  • Ausbeck, Elizabeth B.; Jauk, Victoria C.; Boggess, Kim A.; Saade, George; Longo, Sherri; Esplin, Sean; Cleary, Kirsten; Wapner, Ronald; Letson, Kellett; Owens, Michelle; Blackwell, Sean; Ambalavanan, Namasivayam; Szychowski, Jeff M.; Andrews, William; Tita, Alan T. N.


  • Objective To compare the frequency of postoperative surgical site infection (SSI) by type of skin preparation used for unscheduled cesarean in the setting of adjunctive azithromycin prophylaxis. Methods Secondary analysis of a multi-center randomized controlled trial of adjunctive azithromycin (500 mg intravenous) versus placebo in women who were >= 24 weeks gestation and undergoing unscheduled cesarean (i.e. during labor or >= 4 h after membrane rupture). Type of skin preparation used was identified based on the protocol at the hospital at the time of delivery: iodine-alcohol, chlorhexidine, chlorhexidine-alcohol, or the combination of chlorhexidine-alcohol and iodine. The primary outcome of this analysis was incidence of post-operative SSI, as defined by CDC criteria. Multivariable logistic regression was applied for adjustments. Results All 2013 women in the primary trial were included in this analysis. Women were grouped according to type of skin preparation received: iodine-alcohol (n = 193), chlorhexidine (n = 733), chlorhexidine-alcohol (n = 656), and chlorhexidine-alcohol and iodine combined sequentially (n = 431). The unadjusted rates of wound infection ranged from 2.9% to 5.7%. Using iodine-alcohol as the referent, the adjusted odds ratios for wound SSI were 0.71 (95% CI 0.30-1.66) for chlorhexidine, 0.97 (95% CI 0.41-2.28) for chlorhexidine-alcohol, and 0.88 (95% CI 0.36-2.20) for chlorhexidine-alcohol with iodine combination. Conclusion In women undergoing unscheduled cesarean delivery in a trial of adjunctive azithromycin, the type of skin preparation used did not appear to be associated with the frequency of wound SSI.

Publication date

  • 2020


International Standard Serial Number (ISSN)

  • 1476-7058