Impact of obesity on adverse in-hospital outcomes in patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip (R) procedure - Results from the German nationwide inpatient sample Article

Full Text via DOI: 10.1016/j.numecd.2020.04.009 PMID: 32513574 Web of Science: 000572853200015
International Collaboration

Cited authors

  • Keller, Karsten; Hobohm, Lukas; Geyer, Martin; Kreidel, Felix; Ostad, Mir A.; Lavie, Carl J.; Lankeit, Mareike; Konstantinides, Stavros; Muenzel, Thomas; von Bardeleben, Ralph Stephan


  • Background and aim: The number of percutaneous edge-to-edge mitral regurgitation (MR) valve repairs with MitraClip (R) implantations increased exponentially in recent years. Studies have suggested an obesity survival paradox in patients with cardiovascular diseases. We investigated the influence of obesity on adverse in-hospital outcomes in patients with MitraClip (R) implantation.; Methods and results: We analyzed data on characteristics of patients and in-hospital outcomes for all percutaneous mitral valve repairs using the edge-to-edge MitraClip (R)-technique in Germany 2011-2015 stratified for obesity vs. normal-weight/over-weight.; The nationwide inpatient sample comprised 13,563 inpatients undergoing MitraClip (R) implantations. Among them, 1017 (7.5%) patients were coded with obesity. Obese patients were younger (75 vs.77 years,P < 0.001), more often female (45.4% vs.39.5%,P < 0.001), had more often heart failure (87.1% vs.79.2%,P < 0.001) and renal insufficiency (67.0% vs.56.4%,P < 0.001). Obese and non-obese patients were comparable regarding major adverse cardiac and cerebrovascular events (MACCE) and in-hospital death. The combined endpoint of cardio-pulmonary resuscitation (CPR), mechanical ventilation and death was more often reached in non-obese than in obese patients with a trend towards significance (20.6%vs.18.2%,P <= 0.066). Obesity was an independent predictor of reduced events regarding the combined endpoint of CPR, mechanical ventilation and death (OR 0.75, 95%CI 0.64-0.89,P < 0.001), but not for reduced in-hospital mortality (P = 0.355) or reduced MACCE rate (P = 0.108). Obesity class III was associated with an elevated risk for pulmonary embolism (OR 5.66, 95%CI 1.35-23.77,P = 0.018).; Conclusions: We observed an obesity paradox regarding the combined endpoint of CPR, mechanical ventilation and in-hospital death in patients undergoing MitraClip (R) implantation, but our results failed to confirm an impact of obesity on in-hospital survival or MACCE. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Publication date

  • 2020

International Standard Serial Number (ISSN)

  • 0939-4753

Start page

  • 1365

End page

  • 1374


  • 30


  • 8