Oral insulin: an update Article

Full Text via DOI: 10.23736/S0391-1977.19.03055-4 PMID: 31347343 Web of Science: 000549203900008
International Collaboration

Cited authors

  • Chatterjee, Subhankar; Sharma, Chandra Bhushan; Lavie, Carl J.; Adhikari, Anjan; Deedwania, Prakash; O'Keefe, James H.


  • Insulin, either in its intravenous or subcutaneous forms, remains the standard therapy for virtually all type-1 diabetes and many of the type-2 diabetes patients in its advanced stages. With advancement of injection techniques, insulin therapy has become much more patient-friendly than ever. Still there is vast area of unmet needs regarding current practice of insulin therapy. Insulin injections are associated with poor compliance. weight gain, fears of hypoglycemia and adverse effects of systemic hyperinsulinemia. So, a search for oral insulin tablet which may closely mimic the physiological insulin secretions has always been there. This review intends to briefly describe the existing barriers of oral insulin delivery and strategies to overcome those. It also highlights the recent human studies and tries to find out the future of oral insulin in clinical context.

Publication date

  • 2020

Published in


International Standard Serial Number (ISSN)

  • 0391-1977

Start page

  • 49

End page

  • 60


  • 45


  • 1