Renal Artery Stenosis in the Patient with Hypertension: Prevalence, Impact and Management Article

Full Text via DOI: 10.2147/IBPC.S248579 PMID: 32581575 Web of Science: 000542706700001

Cited authors

  • Manaktala, Rohini; Tafur-Soto, Jose D.; White, Christopher J.


  • Atherosclerosis is the primary cause of renal artery stenosis. Atherosclerotic renal artery stenosis (ARAS) is associated with three clinical problems: renovascular hypertension, ischemic nephropathy and cardiac destabilization syndrome which pose huge healthcare implications. There is a significant rate of natural disease progression with worsening severity of renal artery stenosis when renal revascularization is not pursued in a timely manner. Selective subgroups of individuals with ARAS have had good outcomes after percutaneous renal artery stenting (PTRAS). For example, individuals that underwent PTRAS and had improved renal function were reported to have a 45% survival advantage compared to those without improvement in their renal function. Advances in the imaging tools have allowed for better anatomic and physiologic measurements of ARAS. Measuring translesional hemodynamic gradients has allowed for accurate assessment of ARAS severity. Renal revascularization with PTRAS provides a survival advantage in individuals with significant hemodynamic renal artery stenosis lesions. It is important that we screen, diagnosis, intervene with invasive and medical treatments appropriately in these high-risk patients.

Publication date

  • 2020

Published in


International Standard Serial Number (ISSN)

  • 1178-7104

Start page

  • 71

End page

  • 82


  • 13