Left ventricular hypertrophy and hypertension Article

Full Text via DOI: 10.1016/j.pcad.2019.11.009 PMID: 31759953 Web of Science: 000521520900004

Cited authors

  • Yildiz, Mehmet; Oktay, Ahmet Afsin; Stewart, Merrill H.; Milani, Richard V.; Ventura, Hector O.; Lavie, Carl J.


  • Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease (CVD) morbidity and mortality. The left ventricle (LV) is a primary target for HTN end-organ damage. In addition to being a marker of HTN, LV geometrical changes: concentric remodeling, concentric or eccentric LV hypertrophy (LVH) are major independent risk factors for not only CVD morbidity and mortality but also for all-cause mortality and neurological pathologies. Blood pressure control with lifestyle changes and antihypertensive agents has been demonstrated to prevent and regress LVH. Herein, we provide a comprehensive review of literature on the relationship between HTN and LV geometry abnormalities with a focus on diagnosis, prognosis, pathophysiological mechanisms, and treatment approaches. (C) 2019 Elsevier Inc. All rights reserved.

Publication date

  • 2020

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Start page

  • 10

End page

  • 21


  • 63


  • 1