Total abdominal colectomy is cost-effective in treating colorectal cancer in patients with genetically diagnosed Lynch Syndrome Article

Full Text via DOI: 10.1016/j.amjsurg.2019.03.011 PMID: 30904142 Web of Science: 000490752400020

Cited authors

  • Jiang, Boxiang; Ofshteyn, Asya; Idrees, Jay J.; Giglia, Matthew; Gallego, Carlos; Stein, Sharon L.; Steinhagen, Emily


  • Background: Lynch syndrome (LS) has a 80% lifetime risk of developing colorectal cancer and metachronous cancer. No studies have examined the quality adjusted life expectancy after SEG or TAC for LS patients, which this study was aiming for. If TAC offers a higher quality adjusted life year (QALY) to SEG in LS patients, preoperative diagnosis of LS is critical as it alters the recommended surgical procedure.; Methods: A Markov decision tree was constructed using Treeage software to compare QALY of LS patients following SEG or TAC. Probabilities, cost, and utility were obtained from literature. Cost-effectiveness analyses were performed.; Results: TAC dominates SEG as both the life-saving and cost-saving strategy. TAC dominated SEG on QALY (17.80 vs 17.13 QALY) for a cohort of LS patients diagnosed at an average of 30 year old and followed every 2 years after initial surgery.; Conclusions: We conclude that TAC as the primary surgical option for LS patients diagnosed with Stage IIII colon cancer is cost-effective. Further cost-effectiveness study is recommended to include extracolonic malignancies in LS patients. (C) 2019 Elsevier Inc. All rights reserved.

Publication date

  • 2019

Published in

International Standard Serial Number (ISSN)

  • 0002-9610

Start page

  • 928

End page

  • 933


  • 218


  • 5