Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults Article

Full Text via DOI: 10.1056/NEJMoa1812405 PMID: 30779528 Web of Science: 000459899100006
Highly Cited Paper

Cited authors

  • Casey, Jonathan D.; Janz, David R.; Russell, Derek W.; Vonderhaar, Derek J.; Joffe, Aaron M.; Dischert, Kevin M.; Brown, Ryan M.; Zouk, Aline N.; Gulati, Swati; Heideman, Brent E.; Lester, Michael G.; Toporek, Alexandra H.; Bentov, Itay; Self, Wesley H.; Rice, Todd W.; Semler, Matthew W.


  • Background Hypoxemia is the most common complication during tracheal intubation of critically ill adults and may increase the risk of cardiac arrest and death. Whether positive-pressure ventilation with a bag-mask device (bag-mask ventilation) during tracheal intubation of critically ill adults prevents hypoxemia without increasing the risk of aspiration remains controversial. Methods In a multicenter, randomized trial conducted in seven intensive care units in the United States, we randomly assigned adults undergoing tracheal intubation to receive either ventilation with a bag-mask device or no ventilation between induction and laryngoscopy. The primary outcome was the lowest oxygen saturation observed during the interval between induction and 2 minutes after tracheal intubation. The secondary outcome was the incidence of severe hypoxemia, defined as an oxygen saturation of less than 80%. Results Among the 401 patients enrolled, the median lowest oxygen saturation was 96% (interquartile range, 87 to 99) in the bag-mask ventilation group and 93% (interquartile range, 81 to 99) in the no-ventilation group (P=0.01). A total of 21 patients (10.9%) in the bag-mask ventilation group had severe hypoxemia, as compared with 45 patients (22.8%) in the no-ventilation group (relative risk, 0.48; 95% confidence interval [CI], 0.30 to 0.77). Operator-reported aspiration occurred during 2.5% of intubations in the bag-mask ventilation group and during 4.0% in the no-ventilation group (P=0.41). The incidence of new opacity on chest radiography in the 48 hours after tracheal intubation was 16.4% and 14.8%, respectively (P=0.73). Conclusions Among critically ill adults undergoing tracheal intubation, patients receiving bag-mask ventilation had higher oxygen saturations and a lower incidence of severe hypoxemia than those receiving no ventilation.

Publication date

  • 2019

Published in

International Standard Serial Number (ISSN)

  • 0028-4793

Start page

  • 811

End page

  • 821


  • 380


  • 9