Haddock, Jody H.; Mercante, Donald E.; Paccione, Rose; Breaux, Jacob L.; Jolley, Sarah E.; Johnson, Jessica L.; Connolly, Sean E.; deBoisblanc, Bennett P.
Background: Digital pupillometry (DP) accurately and precisely measures pupillary responses. Little is known about using DP to measure the sedative effect of isolated propofol administration.; Methods: We conducted a cross-sectional study of 19 adults undergoing moderate sedation with propofol during which we measured pupillary changes using DP.; Results: Maximum and minimum pupillary diameters decreased significantly with propofol (mean change from baseline to procedural termination -1.24 mm, standard error [SE] 0.25 and -0.79 mm, SE 0.13, respectively; P <= 0.001 for both). Mean constriction velocity decreased by 0.84 mm/s between baseline and procedural termination (P = 0.001). Pupillary latency increased significantly between baseline and induction (mean change 0.016 seconds, SE 0.007; P = 0.04) but was not significantly different at other time points.; Conclusion: We speculate that DP may be a useful tool to monitor propofol sedation.