Neuroprotection in the Treatment of Acute Ischemic Stroke Article

Full Text via DOI: 10.1016/j.pcad.2017.04.005 PMID: 28465001 Web of Science: 000404824100004

Cited authors

  • Patel, Rajan A. G.; McMullen, Paul W.


  • Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability to protect the ischemic brain from injury until reperfusion and then to protect the brain from reperfusion injury could theoretically improve freedom from disability among stroke survivors. This manuscript reviews the molecular and cellular pathophysiology of stroke and summarizes pharmacologic and other therapies that showed promise in pre-clinical testing as neuroprotection agents. However to date, no compelling efficacy data have been published regarding any pharmacologic or other therapies. Nonetheless the search for effective neuroprotection continues at stroke centers throughout the world. (C) 2017 Elsevier Inc. All rights reserved.

Publication date

  • 2017

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Start page

  • 542

End page

  • 548


  • 59


  • 6