A Practical Approach to Refractory Chronic Rhinosinusitis Article

Full Text via DOI: 10.1016/j.otc.2016.08.014 PMID: 27888913 Web of Science: 000390983700014

Cited authors

  • McCoul, Edward D.; Tabaee, Abtin


  • Patients with refractory chronic rhinosinusitis, by definition, have persistent, poorly controlled symptoms and objective inflammatory findings despite prior medical and surgical therapy. These patients represent a diagnostic and treatment challenge given the complexity of the underlying disease factors and the limitations in available management options. This article presents a practical framework for clinical evaluation and treatment. Germane to discussion are emerging concepts in refractory chronic rhino sinusitis that will likely have important implications in the near future.

Publication date

  • 2017

International Standard Serial Number (ISSN)

  • 0030-6665

Start page

  • 183


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