Elevated Plasma Pancreastatin, but Not Chromogranin A, Predicts Survival in Neuroendocrine Tumors of the Duodenum Article

Full Text via DOI: 10.1016/j.jamcollsurg.2015.12.014 PMID: 26827125 Web of Science: 000374848000038

Cited authors

  • Woltering, Eugene A.; Beyer, David T.; Thiagarajan, Ramcharan; Ramirez, Robert A.; Wang, Yi-Zarn; Ricks, M. Jennifer; Boudreaux, J. Philip


  • BACKGROUND: Neuroendocrine tumors (NETs) of the duodenum are rare, heterogeneous, and often indolent neoplasms. We hypothesized that elevated pancreastatin levels are an indicator of a poor prognosis in well-differentiated duodenal NETs.; STUDY DESIGN: Data from patients diagnosed with a primary duodenal NET were analyzed. Patients that underwent esophogogastroduodenoscopy, endoscopic ultrasound, or exploratory surgery to localize their neoplasm and whose tumors were confirmed histologically were included.; RESULTS: Eighty-four patients were diagnosed with duodenal NETs from January 1991 to January 2014. Seventy-five percent and 21% of patients had their tumor localized by esophogogastroduodenoscopy and endoscopic ultrasound, respectively. The remaining 4% were localized during exploratory surgery. The 5-year Kaplan-Meier survival rate for the entire cohort (N = 84) was 80%. Survival sorted by normal vs abnormal pancreastatin level was statistically significant (p < 0.0001). Five-year survival rates were 94% and 37% for normal and abnormal pancreastatin, respectively. In contrast, survival sorted by normal vs abnormal plasma chromogranin A level was not statistically significant (p = 0.24).; CONCLUSIONS: Patients with primary duodenal NETs have high 5-year survival rates. Serial monitoring of plasma pancreastatin levels can identify patients who have a poor prognosis. (J Am Coll Surg 2016; 222: 534-542. (C) 2016 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.)

Publication date

  • 2016

International Standard Serial Number (ISSN)

  • 1072-7515

Start page

  • 534

End page

  • 542


  • 222


  • 4