Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations Article

Full Text via DOI: 10.1002/oby.21404 PMID: 26935138 Web of Science: 000373613200010

Cited authors

  • Swift, Damon L.; Johannsen, Neil M.; Lavie, Carl J.; Earnest, Conrad P.; Blair, Steven N.; Church, Timothy S.


  • ObjectiveTo determine response rates for clinically significant weight loss (CWL) following different aerobic exercise training amounts and whether enhanced cardiometabolic adaptations are observed with CWL compared to modest weight loss (MWL) or neither.; MethodsParticipants (N=330) performed 6 months of aerobic training at 4 kcal per kilogram per week (KKW), 8 KKW, or 12 KKW (50%, 100%, and 150% of recommended levels respectively). Weight loss was categorized as CWL (5%) or MWL (3.0% to 4.9%) or neither.; ResultsThe CWL response rate was greater in the 8 KKW group (20.2%, CI: 13.0% to 27.5%) compared to 4 KKW (10.3%, CI: 4.6% to 16.0%), but not compared to the 12 KKW group (14.6%, CI: 7.6% to 21.6%). Reductions in HOMA-IR were observed in participants with CWL (-0.60, CI: -0.98 to -0.22) and with MWL (-0.48, CI: -0.87 to -0.10), but not those who achieved neither (-0.06, CI -0.22 to 0.10). No changes between groups were observed for cholesterol, fitness, or blood pressure.; ConclusionsLow response rates for CWL were observed following training, even at levels above recommended levels. Achieving MWL with exercise may represent a reasonable initial weight loss target since the improvement in insulin resistance with MWL is similar to what is achieved with CWL.

Publication date

  • 2016

Published in

International Standard Serial Number (ISSN)

  • 1930-7381

Start page

  • 812

End page

  • 819


  • 24


  • 4