Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection Article

Full Text via DOI: 10.1002/lt.24416 PMID: 26890629 Web of Science: 000373566800008
International Collaboration

Cited authors

  • Fontana, Robert J.; Brown, Robert S., Jr.; Moreno-Zamora, Ana; Prieto, Martin; Joshi, Shobha; Londono, Maria-Carlota; Herzer, Kerstin; Chacko, Kristina R.; Stauber, Rudolf E.; Knop, Viola; Jafri, Syed-Mohammed; Castells, Lluis; Ferenci, Peter; Torti, Carlo; Durand, Christine M.; Loiacono, Laura; Lionetti, Raffaella; Bahirwani, Ranjeeta; Weiland, Ola; Mubarak, Abdullah; ElSharkawy, Ahmed M.; Stadler, Bernhard; Montalbano, Marzia; Berg, Christoph; Pellicelli, Adriano M.; Stenmark, Stephan; Vekeman, Francis; Ionescu-Ittu, Raluca; Emond, Bruno; Reddy, K. Rajender

Abstract

  • Daclatasvir (DCV) is a potent, pangenotypic nonstructural protein 5A inhibitor with demonstrated antiviral efficacy when combined with sofosbuvir (SOF) or simeprevir (SMV) with or without ribavirin (RBV) in patients with chronic hepatitis C virus (HCV) infection. Herein, we report efficacy and safety data for DCV-based all-oral antiviral therapy in liver transplantation (LT) recipients with severe recurrent HCV. DCV at 60mg/day was administered for up to 24 weeks as part of a compassionate use protocol. The study included 97 LT recipients with a mean age of 59.3 +/- 8.2 years; 93% had genotype 1 HCV and 31% had biopsy-proven cirrhosis between the time of LT and the initiation of DCV. The mean Model for End-Stage Liver Disease (MELD) score was 13.0 +/- 6.0, and the proportion with Child-Turcotte-Pugh (CTP) A/B/C was 51%/31%/12%, respectively. Mean HCV RNA at DCV initiation was 14.3x6 log(10) IU/mL, and 37% had severe cholestatic HCV infection. Antiviral regimens were selected by the local investigator and included DCV+SOF (n=77), DCV+SMV (n=18), and DCV+SMV+SOF (n=2); 35% overall received RBV. At the end of treatment (EOT) and 12 weeks after EOT, 88 (91%) and 84 (87%) patients, respectively, were HCV RNA negative or had levels <43 IU/mL. CTP and MELD scores significantly improved between DCV-based treatment initiation and last contact. Three virological breakthroughs and 2 relapses occurred in patients treated with DCV+SMV with or without RBV. None of the 8 patient deaths (6 during and 2 after therapy) were attributed to therapy. In conclusion, DCV-based all-oral antiviral therapy was well tolerated and resulted in a high sustained virological response in LT recipients with severe recurrent HCV infection. Most treated patients experienced stabilization or improvement in their clinical status. Liver Transplantation 22 446-458 2016 AASLD

Publication date

  • 2016

Published in

International Standard Serial Number (ISSN)

  • 1527-6465

Start page

  • 446

End page

  • 458

Volume

  • 22

Issue

  • 4