Update on Obesity and Obesity Paradox in Heart Failure Article

Full Text via DOI: 10.1016/j.pcad.2015.12.003 PMID: 26721180 Web of Science: 000372211900005

Cited authors

  • Lavie, Carl J.; Sharma, Abhishek; Alpert, Martin A.; De Schutter, Alban; Lopez-Jimenez, Francisco; Milani, Richard V.; Ventura, Hector O.


  • Obesity has reached epidemic proportions in most of the Westernized world. Overweightness and obesity adversely impact cardiac structure and function, including on both the right and, especially, left sides of the heart, with adverse affects on systolic and, especially, diastolic ventricular function. Therefore, it is not surprising that obesity markedly increases the prevalence of heart failure (HF). Nevertheless, many studies have documented an obesity paradox in large cohorts with HF, where overweight and obese have a better prognosis, at least in the short-term, compared with lean HF patients. Although weight loss clearly improves cardiac structure and function and reduces symptoms in HF, there are no large studies on the impact of weight loss on clinical events in HF, preventing definitive guidelines on optimal body composition in patients with HF. (C) 2015 Elsevier Inc. All rights reserved.

Publication date

  • 2016

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Start page

  • 393

End page

  • 400


  • 58


  • 4