Pyridoxine deficiency in adult patients with status epilepticus Article

Full Text via DOI: 10.1016/j.yebeh.2015.08.015 PMID: 26418265 Web of Science: 000364990000027

Cited authors

  • Dave, Hina N.; Ramsay, Richard Eugene; Khan, Fawad; Sabharwal, Vivek; Irland, Megan


  • An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 mu g/L. After starting pyridoxine supplementation, improvement in the EEG for a 24-hour period was seen. We decided to look at the pyridoxine levels in adult patients admitted with status epilepticus. We reviewed the records on patients admitted to the neurological ICU for status epilepticus (SE). Eighty-one adult patients were identified with documented pyridoxine levels. For comparison purposes, we looked at pyridoxine levels in outpatients with epilepsy (n=132). Reported normal pyridoxine range is >10 ng/mL. All but six patients admitted for SE had low normal or undetectable pyridoxine levels. A selective pyridoxine deficiency was seen in 94% of patients with status epilepticus (compared to 39.4% in the outpatients) which leads us to believe that there is a relationship between status epilepticus and pyridoxine levels. (C) 2015 Elsevier Inc. All rights reserved.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 1525-5050

Start page

  • 154

End page

  • 158


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