Propofol-ketamine combination therapy for effective control of super-refractory status epilepticus Article

Full Text via DOI: 10.1016/j.yebeh.2015.07.040 PMID: 26523340 Web of Science: 000364990000048

Cited authors

  • Sabharwal, Vivek; Ramsay, Eugene; Martinez, Raisa; Shumate, Rachel; Khan, Fawad; Dave, Hina; Iwuchukwu, Ifeanyi; McGrade, Harold


  • Retrospective analysis was conducted of patients with SRSE who were treated simultaneously with propofol and ketamine. Sixty-seven patients were identified from 2012 to 2015, and outcomes documented were resolution and mortality. The duration of combined ketamine and propofol use ranged from 1 to 28 days (mean -3.6 days). Infusion rates ranged up to 145 and 175 mcg/kg/min. Vasopressors were used in 53 patients (79%), and were given within the first 5 days of the ICU admission in 48 (91%) patients. The overall SRSE resolution rate was 91%, and the overall mortality including patients with anoxic brain injury was 39%. Of the 13 patients with SRSE as a result of anoxic brain injury, SRSE was controlled in 5 (56%). The primary determinant of mortality was family withdrawing care related to the presence of severe medical/neurological diseases. (C) 2015 Elsevier Inc. All rights reserved.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 1525-5050

Start page

  • 264

End page

  • 266


  • 52