Effects of Running on Chronic Diseases and Cardiovascular and All-Cause Mortality Article

Full Text via DOI: 10.1016/j.mayocp.2015.08.001 PMID: 26362561 Web of Science: 000365048500014

Cited authors

  • Lavie, Carl J.; Lee, Duck-chul; Sui, Xuemei; Arena, Ross; O'Keefe, James H.; Church, Timothy S.; Milani, Richard V.; Blair, Steven N.


  • Considerable evidence has established the link between high levels of physical activity (PA) and all-cause and cardiovascular disease (CVD)-specific mortality. Running is a popular form of vigorous PA that has been associated with better overall survival, but there is debate about the dose-response relationship between running and CVD and all-cause survival. In this review, we specifically reviewed studies published in PubMed since 2000 that included at least 500 runners and 5-year follow-up so as to analyze the relationship between vigorous aerobic PA, specifically running, and major health consequences, especially CVD and all-cause mortality. We also made recommendations on the optimal dose of running associated with protection against CVD and premature mortality, as well as briefly discuss the potential cardiotoxicity of a high dose of aerobic exercise, including running (eg, marathons). (C) 2015 Mayo Foundation for Medical Education and Research

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 0025-6196

Start page

  • 1541

End page

  • 1552


  • 90


  • 11