Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology Article

Full Text via DOI: 10.1002/jcph.522 PMID: 25903807 Web of Science: 000360831700005

Cited authors

  • Polepally, Akshanth R.; Remmel, Rory P.; Brundage, Richard C.; Leppik, Ilo E.; Rarick, John O.; Ramsay, R. Eugene; Birnbaum, Angela K.

Abstract

  • A classic 2-period crossover bioavailability study was conducted to evaluate the relative and absolute bioavailability of immediate-release (IR) and extended-release (XR) lamotrigine formulations under steady-state conditions in elderly patients with epilepsy. On treatment days, each subject's morning dose (IR or XR lamotrigine) was replaced with an intravenous 50-mg dose of stable-labeled lamotrigine. Lamotrigine concentrations were measured at 13 points between 0 and 96 hours. XR and IR lamotrigine formulations were similar with respect to steady-state area under the concentration-time curve from 0 to 24 hours (AUC(0-24h) (ss)), average concentration (C-avg,C- ss), and trough concentration (C-,C- ss). A 33% lower fluctuation in concentrations with XR was observed relative to IR lamotrigine. The time to peak concentration (T-max,T- ss) was delayed for XR lamotrigine (3.0 vs 1.3 hours) with lower peak concentration (15% lower). The absolute bioavailability for IR and XR formulations was 73% and 92%, respectively. The formulations were bioequivalent with respect to AUC(0-24h ss), C-,C- ss, and C-avg,C- ss indicating that it may be possible to switch directly from IR to XR lamotrigine without changes in the total daily dose.

Publication date

  • 2015

Published in

Category

International Standard Serial Number (ISSN)

  • 0091-2700

Start page

  • 1101

End page

  • 1108

Volume

  • 55

Issue

  • 10