Safety & pK of IV loading dose of lacosamide in the ICU Article

Full Text via DOI: 10.1016/j.yebeh.2015.06.032 PMID: 26211940 Web of Science: 000359314900062

Cited authors

  • Ramsay, R. Eugene; Sabharwal, Vivek; Khan, Fawad; Dave, Hina; Kafai, Cyrus; Shumate, Rachel; Irland, Megan


  • A restrospective review of patients treated in the ICU for refractoly status epilepticus who had received an initial IV loading dose of lacosamide (LCS) was performed. A total of 142 patients were identified. The first 34 patients received 400 nig which by weight-based measurement ranged from 2 to 11 mg kg.; Higher mg /kg dosing had been used subsequently with doses up to 13 mg /kg. No patient required reduction in rate or cessation of infusion. Initiation of pressor agents was not needed during the infusion of the loading dose. Postinfusion LCS blood levels were drawn, and dosing of 10-12 mg,/kg and higher resulted in blood levels above 15 fig /ml while doses of 2-6 mg kg resulted in levels below 10 pg/ml. We conclude that a weight-based loading dose of 10-12 mg kg at an infusion rate of 0.4 mg/kg/min is safe and will produce levels of 15 ug/ml and higher. 2015 Elsevier Inc. All rights reserved.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 1525-5050

Start page

  • 340

End page

  • 342


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