Evidence-based diuretics: focus on chlorthalidone and indapamide Article

Full Text via DOI: 10.2217/FCA.14.83 PMID: 25760879 Web of Science: 000218669100008

Cited authors

  • DiNicolantonio, James J.; Bhutani, Jaikrit; Lavie, Carl J.; O'Keefe, James H.


  • Thiazide and thiazide-like diuretics are cornerstone treatments for hypertension. However, unlike chlorthalidone (CTD) and indapamide (IDP), hydrochlorothiazide (HCTZ) lacks evidence for reducing morbidity and mortality as monotherapy compared with placebo or control. Despite this fact, HCTZ is prescribed much more frequently than CTD or IDP. We believe that all hypertension guidelines should follow the National Institute for Health and Excellence (NICE) and make IDP and CTD first choice 'thiazide-like diuretics.' This article will focus on the available evidence pertaining to HCTZ versus CTD and IDP. We will review the pharmacological differences between these three diuretics, as well as the clinical trial data and important side effects.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 1479-6678

Start page

  • 203

End page

  • 217


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