Risk Assessment and Management of Anthracycline and HER2 Receptor Inhibitor-Induced Cardiomyopathy Article

Full Text via DOI: 10.14423/SMJ.0000000000000232 PMID: 25688890 Web of Science: 000350052100001

Cited authors

  • Jahangir, Eiman; Shah, Sangeeta; Shum, Kelly; Baxter, Caitlin; Fitzpatrick, Jill D.; Cole, John; Gilliland, Yvonne; Polin, Nichole M.


  • With the advent and increased use of chemotherapeutic agents and radiation therapy, cancer survival rates have increased. With increased survival, both acute and chronic cardiotoxic adverse effects have emerged. The growing need for managing the treatment of individuals with chemotherapy-induced cardiotoxicity has led to the formation of cardio-oncology programs throughout the United States. These programs concentrate on many aspects of cardiac disease in the oncology patient. Of these, the cardiotoxic effects (particularly cardiomyopathy) of anthracyclines and HER2 receptor inhibitors are a large focus of cardio-oncology practice. Despite the increasing availability of these programs, no consensus guidelines have been established to provide a framework for treating these patients. This review describes the initial evaluation, risk assessment, and management of individuals receiving anthracycline and HER2 receptor inhibitor therapy for cardiomyopathy. These recommendations are supported by the current literature in this field.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 0038-4348

Start page

  • 71

End page

  • 78


  • 108


  • 2