Physical Activity and Cardiorespiratory Fitness as Major Markers of Cardiovascular Risk: Their Independent and Interwoven Importance to Health Status Article

Full Text via DOI: 10.1016/j.pcad.2014.09.011 PMID: 25269064 Web of Science: 000348003900004
Highly Cited Paper International Collaboration

Cited authors

  • Myers, Jonathan; McAuley, Paul; Lavie, Carl J.; Despres, Jean-Pierre; Arena, Ross; Kokkinos, Peter


  • The evolution from hunting and gathering to agriculture, followed by industrialization, has had a profound effect on human physical activity (PA) patterns. Current PA patterns are undoubtedly the lowest they have been in human history, with particularly marked declines in recent generations, and future projections indicate further declines around the globe. Non-communicable health problems that afflict current societies are fundamentally attributable to the fact that PA patterns are markedly different than those for which humans were genetically adapted. The advent of modem statistics and epidemiological methods has made it possible to quantify the independent effects of cardiorespiratory fitness (CRP) and PA on health outcomes. Based on more than five decades of epidemiological studies, it is now widely accepted that higher PA patterns and levels of CRF are associated with better health outcomes. This review will discuss the evidence supporting the premise that PA and CRF are independent risk factors for cardiovascular disease (CVD) as well as the interplay between both PA and CRF and other CVD risk factors. A particular focus will be given to the interplay between CRF, metabolic risk and obesity. Published by Elsevier Inc.

Publication date

  • 2015

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Start page

  • 306

End page

  • 314


  • 57


  • 4