Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management Article

Full Text via DOI: 10.1016/j.trsl.2014.04.010 PMID: 24814682 Web of Science: 000342716700010

Cited authors

  • Alpert, Martin A.; Lavie, Carl J.; Agrawal, Harsh; Aggarwal, Kul B.; Kumar, Senthil A.


  • Obesity is a risk factor for heart failure (HF) in both men and women. The mortality risk of overweight and class I and II obese adults with HF is lower than that of normal weight or underweight adults with HF of comparable severity, a phenomenon referred to as the obesity paradox. Severe obesity produces hemodynamic alterations that predispose to changes in cardiac morphology and ventricular function, which may lead to the development of HF. The presence of systemic hypertension, sleep apnea, and hypoventilation, comorbidities that occur commonly with severe obesity, may contribute to HF in such patients. The resultant syndrome is known as obesity cardiomyopathy. Substantial weight loss in severely obese persons is capable of reversing most obesity-related abnormalities of cardiac performance and morphology and improving the clinical manifestations of obesity cardiomyopathy.

Publication date

  • 2014

Published in

International Standard Serial Number (ISSN)

  • 1931-5244

Start page

  • 345

End page

  • 356


  • 164


  • 4