Risk Stratified Usage of Antibiotic-Loaded Bone Cement for Primary Total Knee Arthroplasty: Short Term Infection Outcomes With a Standardized Cement Protocol Article

Full Text via DOI: 10.1016/j.arth.2014.02.032 PMID: 24703363 Web of Science: 000341380000024

Cited authors

  • Qadir, Rabah; Sidhu, Sanbir; Ochsner, J. Lockwood; Meyer, Mark S.; Chimento, George F.


  • Efficacy of antibiotic cement (ALBC) in primary knee arthroplasty (pTKA) has been debated. The study's purpose was to examine efficacy of ALBC versus plain cement (PBC) in preventing infection in high-risk patients undergoing pTKA. 3292 consecutive pTKAs were divided into three cohorts: (1) patients receiving only PBC, (2) patients receiving only ALBC, and (3) only high-risk patients receiving ALBC. Cohorts' infections were compared. The 30-day infection rates for cohorts 1, 2, 3 were 0.29%, 0.20%, and 0.13% respectively. 6-month rates were 0.39%, 0.54% and 0.38%. 1-year rates were 0.78%, 0.61%, and 0.64%. Differences in infection rates at all time intervals were not statistically significant. The study supports that even judicious risk-stratified usage of ALBC may not confer added benefit in decreasing infection at one year. (C) 2014 Elsevier Inc. All rights reserved.

Publication date

  • 2014

Published in

International Standard Serial Number (ISSN)

  • 0883-5403

Start page

  • 1622

End page

  • 1624


  • 29


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