Meta-Analysis Comparing Carvedilol Versus Metoprolol for the Prevention of Postoperative Atrial Fibrillation Following Coronary Artery Bypass Grafting Article

Full Text via DOI: 10.1016/j.amjcard.2013.10.020 PMID: 24332247 Web of Science: 000331161700027
International Collaboration

Cited authors

  • DiNicolantonio, James J.; Beavers, Craig J.; Menezes, Arthur R.; Lavie, Carl J.; O'Keefe, James H.; Meier, Pascal; Vorobcsuk, Andras; Aradi, Daniel; Komocsi, Andras; Chatterjee, Saurav; D'Ascenzo, Fabrizio; Gasparini, Mauro; Brugts, Jasper; Biondi-Zoccai, Giuseppe

Abstract

  • A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. (C) 2014 Elsevier Inc. All rights reserved.

Publication date

  • 2014

Published in

International Standard Serial Number (ISSN)

  • 0002-9149

Start page

  • 565

End page

  • 569

Volume

  • 113

Issue

  • 3