Dexmedetomidine for Anterior Mediastinal Mass Computed Tomography-Guided Biopsy: A Case Series Article

PMID: 24358003 Web of Science: 000420350500014

Cited authors

  • Carollo, Dominic S.; Pestieau, Sophie; Bosco, Richard


  • Background: Sedation of children undergoing biopsies of anterior mediastinal masses can be challenging because of the absolute necessity of ensuring minimal smooth muscle relaxation and preventing airway collapse. Furthermore, positive pressure ventilation may be difficult or impossible and may also pose the additional risks of hemodynamic compromise in the pediatric patient.; Case Reports: We present a case series of 3 children who were successfully sedated for computed tomography (CT)guided mediastinal biopsies with dexmedetomidine.; Conclusion: Dexmedetomidine, a selective alpha-2 adrenoreceptor agonist that maintains the smooth musculature of the pediatric airway, provides the ability to sustain spontaneous ventilation in patients with airway compression. Dexmedetomidine is a safe, reliable anesthetic for biopsy of children with anterior mediastinal masses.

Publication date

  • 2013

Published in

International Standard Serial Number (ISSN)

  • 1524-5012

Start page

  • 541

End page

  • 543


  • 13


  • 4