State-of-the-Art Paper: Therapeutic Hypothermia in Out of Hospital Cardiac Arrest Survivors Article

Full Text via DOI: 10.1002/ccd.24914 PMID: 23475635 Web of Science: 000329285200018

Cited authors

  • Alkadri, Mohi E.; Peters, Matthew N.; Katz, Morgan J.; White, Christopher J.


  • Out of hospital cardiac arrest (OHCA) is associated with an extremely poor survival rate, with mortality in most cases being related to neurological injury. Among patients who experience return of spontaneous circulation (ROSC), therapeutic hypothermia (TH) is the only proven intervention shown to reduce mortality and improve neurological outcome. First described in 1958, the field of TH has rapidly evolved in recent years. While recent technological advances in TH will likely improve outcomes in OHCA survivors, several fundamental questions remain to be answered including the optimal speed of cooling, which patients benefit from an early invasive strategy, and whether technological advances will facilitate application of TH in the field. An increased awareness and understanding of TH strategies, devices, monitoring, techniques, and complications will allow for a more widespread adoption of this important treatment modality. (c) 2013 Wiley Periodicals, Inc.

Publication date

  • 2013

International Standard Serial Number (ISSN)

  • 1522-1946

Start page

  • E482

End page

  • E490


  • 82


  • 4