Impact of Obesity and the Obesity Paradox on Prevalence and Prognosis in Heart Failure Article

Full Text via DOI: 10.1016/j.jchf.2013.01.006 PMID: 24621833 Web of Science: 000209535400001
Highly Cited Paper

Cited authors

  • Lavie, Carl J.; Alpert, Martin A.; Arena, Ross; Mehra, Mandeep R.; Milani, Richard V.; Ventura, Hector O.


  • Obesity has reached epidemic proportions in the United States and worldwide. Considering the adverse effects of obesity on left ventricular (LV) structure, diastolic and systolic function, and other risk factors for heart failure (HF), including hypertension and coronary heart disease, HF incidence and prevalence, not surprisingly, is markedly increased in obese patients. Nevertheless, as with most other cardiovascular diseases, numerous studies have documented an obesity paradox, in which overweight and obese patients, defined by body mass index, percent body fat, or central obesity, demonstrate a better prognosis compared with lean or underweight HF patients. This review will describe the data on obesity in the context of cardiopulmonary exercise testing in HF. Additionally, the implications of obesity on LV assist devices and heart transplantation are reviewed. Finally, despite the obesity paradox, we address the current state of weight reduction in HF. (C) 2013 by the American College of Cardiology Foundation

Publication date

  • 2013

Published in

International Standard Serial Number (ISSN)

  • 2213-1779

Start page

  • 93

End page

  • 102


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