Cancer Stem Cell and Stromal Microenvironment Article

PMID: 23531695 Web of Science: 000420261000016

Cited authors

  • Li, Li; Cole, John; Margolin, David A.


  • Background: Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence.; Methods: We illustrate the key roles that cancer stem cells and the tumor microenvironment-particularly the lymph node stromal microenvironment-play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma.; Conclusion: We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling-targeted therapy, may effectively minimize cancer recurrence.


Publication date

  • 2013

Published in

International Standard Serial Number (ISSN)

  • 1524-5012

Start page

  • 109

End page

  • 118


  • 13


  • 1