Cellular Mechanisms of Brain Injury and Cell Death Article

Full Text via DOI: 10.2174/138161212803832425 PMID: 22762474 Web of Science: 000310579800017

Cited authors

  • Schubert, Armin; Emory, Logan


  • An array of clinical events may lead to perioperative neurological injury. We first review the general cellular mechanisms leading to brain tissue injury and death. The genesis and mechanisms of injury after cerebral aneurysm surgery, traumatic brain injury, postoperative vascular insult in patients with severe cerebrovascular disease are discussed, as are strategies for prevention and treatment. More has become known about the epidemiology, risk factors and potential preventive strategies in postoperative delirium, and, to a lesser extent, postoperative cognitive dysfunction. Finally, emerging concepts in clinical brain protection are discussed, including preconditioning, gene therapy and stem cells.

Publication date

  • 2012

Published in


International Standard Serial Number (ISSN)

  • 1381-6128

Start page

  • 6325

End page

  • 6330


  • 18


  • 38