Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae

Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae Article

Full Text via DOI: 10.1016/j.diagmicrobio.2011.05.003 PMID: 21767715 Web of Science: 000293316900027

Polymyxin B (PB) plus meropenem (MER) or rifampin (RIF) was tested by Etest (R) method and time-kill assay (TKA) against 14 genetically unique clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. PB + MER: Etest, 43% synergy; TKA, 64% synergy. Concordance between methods was 79%. For PB + RIF: Etest, 21% synergy; TKA, 100% synergy. Concordance between methods was 21%. (C) 2011 Elsevier Inc. All rights reserved.