Improving Donor Livers by Inhibiting TNF-alpha Production Article

PMID: 21603393 Web of Science: 000420213900008

Cited authors

  • Zetzmann, Christopher P.; Swamy, O. Rama; Loss, George E., Jr.; Bohorquez, Humberto; Cohen, Ari J.


  • Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver.

Publication date

  • 2010

Published in

International Standard Serial Number (ISSN)

  • 1524-5012

Start page

  • 250

End page

  • 255


  • 10


  • 4