Usefulness of Precordial T-Wave Inversion to Distinguish Arrhythmogenic Right Ventricular Cardiomyopathy from Idiopathic Ventricular Tachycardia Arising from the Right Ventricular Outflow Tract Article

Full Text via DOI: 10.1016/j.amjcard.2010.01.365 PMID: 20538137 Web of Science: 000279378100029

Cited authors

  • Morin, Daniel P.; Mauer, Andreas C.; Gear, Kathleen; Zareba, Wojciech; Markowitz, Steven M.; Marcus, Frank I.; Lerman, Bruce B.


  • The 2 predominant causes of ventricular tachycardia (VT) arising from the right ventricle are arrhythmogenic right ventricular cardiomyopathy (ARVC) and idiopathic VT arising from the right ventricular outflow tract (RVOT). These arrhythmias can be adrenergically mediated and may be difficult to distinguish clinically. A minor criterion for the diagnosis of ARVC is T-wave inversion (TWI) in the right precordial leads during sinus rhythm. However, there have been reports of precordial TWI identified in patients with RVOT tachycardia. The purpose of this study was to determine whether patterns of precordial TWI could differentiate between the 2 groups. A multicenter registry of 229 patients with VT of right ventricular origin was evaluated. After appropriate exclusions (n = 29), 79 patients (58% men, mean age 40 +/- 14 years) had ARVC, and 121 patients (41% men, mean age 48 +/- 14 years) had RVOT tachycardia. During sinus rhythm, 37 patients (47%) with ARVC and 5 patients (4%) with RVOT tachycardia had TWI in leads V(1) to V(3). For the diagnosis of ARVC, TWI in leads V(1) to V(3) had sensitivity of 47% and specificity of 96%. In conclusion, in patients with VT of right ventricular origin, the presence of TWI in electrocardiographic leads V(1) to V(3) supports the diagnosis of ARVC. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;105:1821-1824)

Publication date

  • 2010

Published in

International Standard Serial Number (ISSN)

  • 0002-9149

Start page

  • 1821

End page

  • 1824


  • 105


  • 12