- Ventura, Hector; Bichara, Valentina M.
- Heart failure (HF) remains a most prevalent disease in Western countries. This is a very complex multifactorial disease, associated with a large number of comorbidities. Cardiac cachexia is not uncommon in those patients with advanced heart failure. While there are unknown mechanisms for cardiac cachexia in HF patients, it's known that it is a poor prognosis marker in those patients with further deterioration of their clinical status. Authors attribute the development of cachexia in HF to the presence of an abnormal metabolism, with greater catabolic products as a result of an imbalance between catabolism and reduced anabolism in advanced stages of HF. It has also been shown that certain metabolic factors, considered risk factors for cardiovascular disease, are associated with better prognosis in patients with HF. Several publications have seen an inverse relationship in terms of mortality in overweight or obesity patients with HF. Some authors have called these findings "reverse epidemiology". It has also been shown the association of high cholesterol levels with low levels of inflammatory cytokines in different studies.; Metabolic abnormalities misuse of energy reserves plays an important role in the mechanism of HF. For all this reasons, the modulation of cardiac metabolism is a promising new approach for the treatment of HF.; The aim of this review was to analyze the influence degree that generates metabolic abnormalities in patients with advanced heart failure and how this progression contributes for further deterioration of their clinical status.
International Standard Serial Number (ISSN)
Additional Document Info