Role of the RhoA/Rho-kinase pathway in the regulation of pulmonary vasoconstrictor function Article

Full Text via DOI: 10.1139/Y09-092 PMID: 20130732 Web of Science: 000275273800001

Cited authors

  • Nossaman, Bobby D.; Nossaman, Vaughn E.; Murthy, Subramanyam N.; Kadowitz, Philip J.


  • Calcium is the major intracellular messenger that triggers smooth muscle contraction. The study of calcium-binding proteins, such as calmodulin and its downstream effectors, reveals critical regulation of smooth muscle Contraction by protein kinases and phosphatases. Moreover, the small GTP-binding protein RhoA and its downstream effector protein, Rho-kinase, have been shown to play a novel role in the regulation of smooth muscle contraction. Studies have shown that the activation of Rho-kinase is involved in the development of endothelial dysfunction, inflammation, restenosis, and increased vascular tone in a number of cardiovascular disorders. Because inhibitors of this pathway promote vasodilation independent of the mechanism that increases vasoconstrictor tone, it is our hypothesis that Rho-kinase is constitutively active in regulating vasoconstrictor tone in the pulmonary and systemic vascular beds. Studies in the literature suggest that the RhoA/Rho-kinase pathway has an important role in the pathogenesis of pulmonary hypertension.

Publication date

  • 2010

International Standard Serial Number (ISSN)

  • 0008-4212

Start page

  • 1

End page

  • 8


  • 88


  • 1