Primary and Secondary Prevention of Cardiovascular Diseases: A Practical Evidence-Based Approach Article

Full Text via DOI: 10.4065/84.8.741 PMID: 19648392 Web of Science: 000268685600011

Cited authors

  • O'Keefe, James H.; Carter, Maia D.; Lavie, Carl J.


  • Despite the fact that we possess highly effective tools for the primary and secondary prevention of myocardial Infarction and other complications of atherosclerosis, coronary heart disease remains the most common cause of death In our society. Arterial Inflammation and endothelial dysfunction play central roles In the pathogenesis of atherosclerosis and adverse cardiovascular (CV) events. Therapeutic lifestyle changes In conjunction with an aggressive multidrug regimen targeted toward the normalization of the major CV risk factors will neutralize the atherogenic milieu, reduce vascular Inflammation, and markedly decrease the risk of adverse CV events and need for revascularization procedures. Specific CV risk factors and optimal therapies for primary and secondary prevention are discussed.

Publication date

  • 2009

Published in

International Standard Serial Number (ISSN)

  • 0025-6196

Start page

  • 741

End page

  • 757


  • 84


  • 8