MANAGEMENT OF HEAD AND NECK PARAGANGLIOMAS: REVIEW OF 120 PATIENTS Article

Full Text via DOI: 10.1002/hed.20967 PMID: 18972432 Web of Science: 000264011500012
International Collaboration

Cited authors

  • Papaspyrou, Konstantinos; Mann, Wolf J.; Amedee, Ronald G.

Abstract

  • Background. Head and neck paragangliomas (PGL) are rare. mostly benign tumors. About 10% to 15%, of PGL are caused by mutations in the succinate dehydrogenase genes 3, C. or D and may appear multifocally.; Methods and Results. A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT). 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included, The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 9201,, of JTT and 88% of TT resections.; Conclusion. According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. (C) 2008 Wiley Periodicals, Inc. Head Neck 31: 381-387, 2009

Publication date

  • 2009

Published in

International Standard Serial Number (ISSN)

  • 1043-3074

Start page

  • 381

End page

  • 387

Volume

  • 31

Issue

  • 3