Endovascular therapy for critical limb ischemia Article

Full Text via DOI: 10.1177/1358863X07087129 PMID: 18687765 Web of Science: 000259081900009

Cited authors

  • Arain, Salman A.; White, Christopher J.


  • Chronic critical limb ischemia (CLI) occurs when arterial perfusion is reduced below a threshold level that results in rest pain and/or tissue breakdown in the lower extremities. Importantly, it is associated with high cardiovascular morbidity and mortality. Without prompt revascularization, CLI may result in loss of a limb (i.e. amputation) and/or life. The goal of endovascular therapy is the re-establishment of pulsatile, straight-line flow to the distal extremity. Percutaneous transluminal angioplasty (PTA) has been shown to be effective and safe in the setting of CLI, with limb salvage rates that compare favorably with surgical procedures. Stents are indicated for failed PTA, while adjunctive therapies such as lasers, thermal angioplasty and atherectomy devices lack data demonstrating improved efficacy compared with conventional lower extremity interventions. In addition to successful revascularization, the institution of lifestyle changes, atherosclerotic risk factor modification, and pharmacologic therapies are indicated to reduce cardiovascular morbidity and mortality.

Publication date

  • 2008

Published in

International Standard Serial Number (ISSN)

  • 1358-863X

Start page

  • 267

End page

  • 279


  • 13


  • 3