Prognostic value of cardiopulmonary exercise test after heart transplantation Article

Full Text via DOI: 10.1111/ctr.14387 Web of Science: 000667495600001
International Collaboration

Cited authors

  • Iglesias D, Masson W, Barbagelata L, Rossi E, Mora M, Cornejo G, Lagoria J, Belziti C, Vulcano N, Marenchino R, Pizarro R, Ventura H


  • Background The clinical utility of cardiopulmonary exercise testing (CPET) has not been extensively studied yet in heart transplantation (HTX) patients. Objective To analyze the predictive value of the CPET on hospitalizations and mortality in HTX recipients. Methods A retrospective cohort was performed from a secondary database. Patients > 18 years with HTX who underwent a CPET between 3 and 12 months after transplantation were included. Time to the first primary endpoint (HTX-related hospitalization) was analyzed and adjusted using Cox proportional hazards regression model. Results A total of 122 patients (mean age 50.1 years, 77.0% men) were included. Fifty-seven patients (46.7%) had the primary endpoint. Peak VO2 (HR .95; CI 95% .90-.99, P = .03), oxygen pulse (HR .57; CI 95% .34-.96, P = .03) and predicted VO2 (HR .97; CI 95% .96-.99, P = .002) were associated with the endpoint. We did not find a significant association between the other variables and the outcome. Conclusion In HTX recipients, peak VO2, oxygen pulse, and predicted VO2 were independently associated with hospitalizations at follow up.

Publication date

  • 2021

Published in


International Standard Serial Number (ISSN)

  • 0902-0063

Number of pages

  • 7