Interactions of hypertension, obesity, left ventricular hypertrophy, and heart failure Article

Full Text via DOI: 10.1097/HCO.0000000000000868 Web of Science: 000661895200012

Cited authors

  • daSilva-deAbreu A, Alhafez BA, Lavie CJ, Milani RV, Ventura HO


  • Purpose of review Hypertension (HTN) and obesity are major risk factors for cardiac remodeling and dysfunction, leading to left ventricular hypertrophy (LVH) and heart failure (HF). In this review, we discuss the complex mechanisms and effects of HTN and obesity, and their treatments in LVH, ventricular function, and HF. Recent findings Obesity and HTN impact the heart through overlapping neurohormonal pathways. However, the relationship between obesity and cardiomyopathy is more complex, and additional metabolic and hemodynamic pathways seem to contribute to cardiac dysfunction in these patients. Weight loss and blood pressure (BP) control help to prevent and reverse at least some of the damage caused by obesity and HTN even beyond what would be expected from solely the hemodynamic changes. Obesity and HTN cause maladaptive changes in the heart that can lead to LVH and HF. Weight loss and BP control help to, at least partially, reverse some of these changes and improve clinical outcomes in patients with HF.

Publication date

  • 2021

Published in

International Standard Serial Number (ISSN)

  • 0268-4705

Number of pages

  • 8

Start page

  • 453

End page

  • 460


  • 36


  • 4