Pathogenic Role of Epstein-Barr Virus in Lung Cancers Article

Full Text via DOI: 10.3390/v13050877 Web of Science: 000654626100001
Open Access International Collaboration

Cited authors

  • Becnel D, Abdelghani R, Nanbo A, Avilala J, Kahn J, Li L, Lin Z


  • Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein-Barr virus (EBV) is the first identified human oncogenic virus and it alone causes similar to 200,000 cancer cases and similar to 1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.

Publication date

  • 2021

Number of pages

  • 15


  • 13


  • 5