Beltran-Garcia J, Osca-Verdegal R, Nacher-Sendra E, Cardona-Monzonis A, Sanchis-Gomar F, Carbonell N, Pallardo FV, Lavie CJ, Garcia-Gimenez JL
The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, includ-ing microRNAs, long non-coding RNAs, and circular RNAs, playa crucial role in genetic reprogramming, gene reg-ulation, and inflammation during the development of CVD. Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mech-anisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies. (c) 2021 Elsevier Inc. All rights reserved.