Prosthesis-patient mismatch following aortic and mitral valves replacement - A comprehensive review Article

Full Text via DOI: 10.1016/j.pcad.2022.02.004 Web of Science: 000853226100011

Cited authors

  • Joury A, Duran A, Stewart M, Gilliland YE, Spindel SM, Qamruddin S


  • Prothesis-patient mismatch (PPM) occurs when there is a mismatch between the effective orifice area (EOA) of the prosthetic valve and the required cardiac output to meet the need of the patient's body surface area (BSA). The clinical threshold for PPMoccurswhen the indexed effective orifice area (iEOA) is <= 0.65cm(2)/m(2) for the aortic valve prosthesis, and <= 1.20 cm(2)/m(2) for the mitral valve prosthesis. The wide variation of reported incidence of PPMismost likely attributed to the variation in the methods of calculating iEOA [(for e.g., using continuity equation across the prosthesis versus using projected EOA(generated by the industry)]. Newer generationmechanical valves have shown less PPM than older generation, and stentless bioprosthesis have less PPM than stented prosthesis.Long-termclinical outcome of PPMis associatedwith adverse cardiovascular events especially in the presence of pre-existing left ventricle dysfunction or with concomitant procedure such as coronary artery bypass graft surgery. Strategies to mitigate the risk of PPM such as aortic root replacement in patients with the small aortic annulus should be utilized. Accurate assessment of the patient's annular size and indexing the effective orifice area (EOA) of the prosthesis to patient's BSA at the time of prosthesis implantation are important steps to preventing future PPM. (C) 2022 Elsevier Inc. All rights reserved.

Publication date

  • 2022

Published in

International Standard Serial Number (ISSN)

  • 0033-0620

Number of pages

  • 9

Start page

  • 84

End page

  • 92


  • 72