Subclavian artery stenosis is a disease entity that is often under-diagnosed and overlooked, however if left untreated can present with grave neurologic, cerebrovascular, cardiac, and upper extremity complications. Diagnosis begins with a thorough history and physical exam, including bilateral arm blood pressures. Once suspected, non-invasive imaging is conducted followed by catheter-based angiography. Endovascular intervention offers minimally invasive treatment with high success rates and infrequent complications.