IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry Article

Full Text via DOI: 10.1038/srep41920 PMID: 28157220 Web of Science: 000393372800001
Open Access International Collaboration

Cited authors

  • Carolina Sanabria-Salas, Maria; Hernandez-Suarez, Gustavo; Umana-Perez, Adriana; Rawlik, Konrad; Tenesa, Albert; Lucia Serrano-Lopez, Martha; Sanchez de Gomez, Myriam; Patricia Rojas, Martha; Eduardo Bravo, Luis; Albis, Rosario; Luis Plata, Jose; Green, Heather; Borgovan, Theodor; Li, Li; Majumdar, Sumana; Garai, Jone; Lee, Edward; Ashktorab, Hassan; Brim, Hassan; Li, Li; Margolin, David; Fejerman, Laura; Zabaleta, Jovanny


  • Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotype block of the IL1B (-3737C/-1464G/-511T/-31C) and CRC risk, and this association was exclusively observed in individuals with a higher proportion of African ancestry, such as individuals from the Coastal Colombian region (odds ratio, OR 2.06; 95% CI 1.31-3.25; p < 0.01). Moreover, a significant interaction between this CRC risk haplotype and local African ancestry dosage was identified in locus 2q14 (p = 0.03). We conclude that Colombian individuals with high African ancestry proportions at locus 2q14 harbour more IL1B-CGTC copies and are consequently at an increased risk of CRC. This haplotype has been previously found to increase the IL1B promoter activity and is the most frequent haplotype in African Americans. Despite of limitations in the number of samples and the lack of functional analysis to examine the effect of these haplotypes on CRC cell lines, our results suggest that inflammation and ethnicity play a major role in the modulation of CRC risk.

Publication date

  • 2017

Published in

International Standard Serial Number (ISSN)

  • 2045-2322


  • 7