Multiple Myeloma Relapse Following Autologous Stem Cell Transplant Presenting With Diffuse Pulmonary Nodules Article

PMID: 24358007 Web of Science: 000420350500018

Cited authors

  • Sumrall, Bradley; Diethelm, Lisa; Brown, Archie, Jr.


  • Background: Multiple myeloma is a common disease, accounting for about 10% of hematologic malignancies in the United States. For eligible patients, the treatment of choice includes induction therapy (usually involving newer biologic agents) followed by autologous stem cell transplant; however, this treatment is generally not considered curative, and relapses usually occur. However, extramedullary relapse is an uncommon presentation, and relapses that involve the lungs have only rarely been described.; Case Report: We report the case of a patient who underwent an autologous stem cell transplant for multiple myeloma and subsequently relapsed with diffuse pulmonary nodules. She then had a rapid clinical and serologic response following initiation of salvage therapy.; Conclusion: This case is remarkable for both the radiographic appearance of the pulmonary involvement, as well as the rapid resolution of these findings after 2 cycles of treatment with bortezomib, dexamethasone, and lenalidomide.

Publication date

  • 2013

Published in

International Standard Serial Number (ISSN)

  • 1524-5012

Start page

  • 553

End page

  • 557


  • 13


  • 4