Factors related to a clinically silent peri-procedural drop in hemoglobin with coronary and peripheral vascular interventions Article

Full Text via DOI: 10.1177/1358863X11417622 PMID: 22003001 Web of Science: 000295880400005

Cited authors

  • Jaffery, Zehra; White, Christopher J.; Collins, Tyrone J.; Grise, Mark A.; Jenkins, J. Stephen; McMullan, Paul W.; Patel, Rajan A.; Reilly, John P.; Thornton, Stanley N.; Ramee, Stephen R.


  • Clinically evident and subclinical peri-procedural bleeding following interventional therapies are associated with adverse cardiovascular outcomes. The risk factors for clinically evident bleeding have been well described. Despite the well-documented association of adverse outcomes for patients with a subclinical peri-procedural hemoglobin drop, the clinical predictors have not yet been defined. We identified 1176 consecutive patients with a subclinical drop in hemoglobin (fall of >= 1 g/dl in patients without clinical bleeding) following percutaneous coronary interventions (PCI) and peripheral vascular interventions (PVI). Multivariate logistic regression analysis was performed. A subclinical peri-procedural hemoglobin drop >= 1 g/dl was identified in 41% (400/972) of PCI and in 49% (213/435) of PVI. More than one access site predicted a higher risk of a subclinical drop in hemoglobin in both groups. A body mass index >= 30 predicted a lower risk of a subclinical drop in hemoglobin in both groups. For PCI, creatinine clearance < 60 ml/min was associated with a higher risk of a subclinical drop in hemoglobin. In conclusion, clinically silent peri-procedural hemoglobin fall >= 1 g/dl is common in patients undergoing both coronary and peripheral percutaneous intervention. Predictors identified in our study will need prospective validation.

Publication date

  • 2011

Published in

International Standard Serial Number (ISSN)

  • 1358-863X

Start page

  • 354

End page

  • 359


  • 16


  • 5